Help connect to clusterX.us.messagelabs.com Connection timed out

I need a solution

hi  messagelabs

Our mail server mail.ruihesoft.com 112.65.245.173 can not send email to our customers and suppliers who use messagelabs.com this month
It maybe block by messagelabs.com 
Please help

postfix log 

 postfix/smtp[31764]: connect to cluster6.us.messagelabs.com[216.82.251.38]:25: Connection timed out

 postfix/smtp[31764]: connect to cluster6.us.messagelabs.com[216.82.249.212]:25: Connection timed out

 postfix/smtp[31764]: connect to cluster6.us.messagelabs.com[216.82.242.46]:25: Connection timed out

postfix/smtp[31764]: AB0F12026C: to=<cherry.lu@autodesk.com>, relay=none, delay=105, delays=0.07/0/105/0, dsn=4.4.1, status=deferred (connect to cluster6.us.messagelabs.com[216.82.242.36]:25: Connection timed out)

 postfix/smtp[32549]: connect to cluster6.us.messagelabs.com[216.82.242.36]:25: Connection timed out

postfix/smtp[639]: connect to cluster6.us.messagelabs.com[216.82.241.100]:25: Connection timed out

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