In Nutanix 5.0, there is only Prism Elements, so there is no problem.
For Nutanix 5.5, you must configure the connector to communicate directly to a host, and nt the Prism Central server.
For Nutanix AHV 5.6 and 5.7, the host needs to unregistered from Prism Central. Nutanix 5.6 and 5.7 disables NFS access when a host or cluster is added to a Prism Central server. So you must make sure the host or cluster that App Layering will be directly communicating with is not part of Prism Central.
NFS access to the hosts was returned in AHV 5.8 so App Layering can still connect to the hosts even they are managed by Prism Central. If at all possible, we recommend upgrading to Nutanix 5.8. You must still set the Connector to communicate only with a single host or cluster, but NFS will work properly and we will be able to perform layering operations.