216.82.251.230 does not like recipient. Remote host said: 421 Service Temporarily Unavailable

I need a solution

Hello we are trying to send email to <user>@interoute.com, from mail.escom.bg and recieve failure notice from our server:

216.82.251.230 does not like recipient.
Remote host said: 421 Service Temporarily Unavailable 
0

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