Workaround:
The current number in use can be checked by looking at:
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$ ls /proc/$(pidof varstored-guard)/fd | wc -l
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and if that number gets close to 4000 to restart toolstack:
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$ xe-toolstack-restart
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Hotfix XS82ECU1011 has been released for this issue, please download and apply the following hotfix to fix this issue:
https://support.citrix.com/article/CTX463430